phenobarbital will reduce the extent or outcome of ramelteon by influencing hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Not known.

phenobarbital will decrease the extent or effect of buprenorphine transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.

phenobarbital will minimize the level or result of parecoxib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified.

phenobarbital will reduce the level or outcome of norgestrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Contraceptive failure is feasible owing to decreased serum concentration of norgestrel.

早期當作安眠藥使用，因為副作用過大已經停止使用，現多用於安樂死，例如瑞士的安樂死即使用此藥物。美國聯邦監獄死刑注射藥物。

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phenobarbital will lower the extent or impact of darunavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with phenobarbital may possibly result in loss of therapeutic outcome and growth of resistance to darunavir

phenobarbital will lower the level or influence of avanafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. For people with ED, check reaction cautiously as a result of prospective for lowered efficiency.

phenobarbital will reduce the level or result of brivaracetam by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Check. Brivaracetam plasma concentration lessened by 19%.

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phenobarbital will lower the level or impact of duvelisib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration with a powerful CYP3A inducer decreases duvelisib location under the curve (AUC), which can cut down duvelisib efficacy.

phenobarbital will lower the extent or effect of ramelteon by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unfamiliar.

Not often, the usage of barbiturates results in localized or subtle myalgic, neuralgic, or arthritic ache, especially in psychoneurotic people with insomnia. The pain may perhaps show up in paroxysms, is most extreme within the early early morning hours, which is most frequently situated in the location on the neck, shoulder girdle, and higher limbs. Indications may possibly last for days once the drug is discontinued.

If signs of withdrawal manifest on the primary working day of cure, a loading dose of a hundred to two hundred mg of phenobarbital can be administered IM Besides the oral dose. Soon after stabilization on phenobarbital, the total get more info everyday dose is diminished by thirty mg/day providing withdrawal is continuing easily. A modification of this regimen requires initiating treatment method within the affected individual’s regular dosage amount and lowering the each day dosage by 10% if tolerated through the affected person.